The data show that by adding CAN04, response rates are higher than historical data using these standard first line chemotherapies alone. 4 out of 7 evaluable patients with metastatic pancreatic cancer (PDAC) and 2 out of 3 patients with metastatic non-small cell lung cancer (NSCLC), including 1 patient with complete response (CR), had objective responses.

Cantargia presenterar nya prekliniska data på CAN04 i kombination med cellgifter på 2020 AACR Annual Meeting. Cantargia AB (“Cantargia”)

The results from this trial, together with the data generated on CAN04 in combination with platinum-based chemotherapy, will be the basis for studies of CAN04 in combination with pembrolizumab and chemotherapy. Uppdaterade data kommer redovisas vid presentationen den 2 juni, 2019. Cantargia utvecklar antikroppsbaserade läkemedel mot interleukin 1 receptor accessory protein (IL1RAP). Antikroppen CAN04 binder IL1RAP med hög affinitet och fungerar genom ADCC och blockad av signalering från interleukin 1.

Can04 data

About CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of IL-1α and IL-1β signaling. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 Här undersöks CAN04 både som monoterapi liksom i kombinationsterapi med två olika cellgiftsregimer i patienter med icke-småcellig lungcancer eller bukspottskörtelcancer (www.clinicaltrials.gov). Under 2019 rapporterade Cantargia positiva prekliniska data kring kombination av CAN04 och platinabaserade cellgifter och dessa studier CAN04 studeras i en fas IIa klinisk studie för behandling av icke-småcellig lungcancer (NSCLC) och bukspottkörtelcancer (PDAC). Nya data har genererats med hjälp av immunhistokemi i tumörprover från 15 patienter. IL1RAP återfanns i tumörens mikromiljö i samtliga prover och cirka 80 % av patienterna hade IL1RAP-positiva cancerceller.

Preclinical data show that CAN04 Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP). The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment. · Both parts of the IL-1 system are upregulated in tumor tissue after chemotherapy · CAN04, blocking the activity of both forms of IL-1, increases the efficacy of several different | January 10, 2021 About CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of IL-1a and IL-1ß signaling.

CAN04 is however an ADCC-enhanced antibody lacking fucose produced by the Potelligent ® technology. The new results show that similar modifications can be introduced in mouse surrogate antibodies. Afucosylation of murine antibodies leads to enhanced binding to receptors present on immune cells, a stronger immune-cell mediated killing and a more pronounced antitumor effect.

PRESS RELEASE PR Newswire . Jun. 22, 2020, 03:13 PM "Vi är glada över att kunna presentera nya data på CAN04 i kombination med cellgifter på denna viktiga cancerkonferens.

CAN04 läggs till cellgiftsbehandling. Sannolikt kommer en uppdatering från studien, inklusive data kring progressionsfri överlevnad,

Cantargia utvecklar antikroppsbaserade läkemedel mot interleukin-1 receptor accessory protein (IL1RAP). Antikroppen CAN04 binder IL1RAP med hög affinititet och fungerar både genom blockad av IL-1-signalering samt s k Antibody-Dependent Cellular Cytotoxicity (ADCC). Prekliniska data visar att CAN04 kan öka effekten av cellgifter. SvD Näringsliv - nyheter inom ekonomi och näringsliv, aktier och börs. Bevakning av internationella affärer och marknader. Motor- och IT-nyheter.

Publicerad: 2020-05-15 (Cision) Cantargia AB (publ) today presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab) in a poster presentation at the ESMO Congress 2018 in Munich, Germany. Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented. Inom lungcancer, där CAN04 visade upp ännu starkare preliminära data förra året, återstår troligen mer insamling av data innan ledningen kan positionera CAN04 i det nya landskap som behandlingen av icke-småcellig lungcancer hamnat i efter introduktionen av anti-PD1 antikroppar, som Keytruda. Cantargia utvecklar antikroppsbaserade läkemedel mot interleukin-1 receptor accessory protein (IL1RAP). Antikroppen CAN04 binder IL1RAP med hög affinititet och fungerar både genom blockad av IL-1-signalering samt s k Antibody-Dependent Cellular Cytotoxicity (ADCC). Prekliniska data visar att CAN04 kan öka effekten av cellgifter.
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The results show synergistic/additive effects of combining CAN04 with the three different registered platinum-based therapies: cisplatin, carboplatin or oxaliplatin in tumor bearing mice. CAN04 increased the anti-tumor effects in mice when combined with different registered platinum-based therapies (cisplatin, carboplatin or oxaliplatin) in either a patient-derived NSCLC model or mouse colon cancer model. Enhanced effects of CAN04 was also observed in combination with two commonly used platinum doublets, cis/gem and oxaliplatin/5-FU. CAN04 studeras i en öppen klinisk fas I/IIa-prövning, CANFOUR, som undersöker första linjens kemoterapikombination med två olika standardregimer hos 31 patienter med NSCLC (gemcitabin/cisplatin) och 31 patienter med PDAC (gemcitabin/nab-paclitaxel), samt monoterapi hos patienter i sen fas (www.clinicaltrials.gov). During 2019, Cantargia also reported positive preclinical data on the combination of CAN04 and platinum-based compounds.

CAN04 is investigated in an open label phase I/IIa The data show that by adding CAN04, response rates are higher than historical data using these standard first line chemotherapies alone.
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CAN04 studeras i en fas I/IIa klinisk studie, CANFOUR, som undersöker Cantargia presents new preclinical data on CAN04 at the 2020 AACR Annual Meeting januari 13, 2021; Truly Labs part of Biobarrier research profile at Malmö Upload, livestream, and create your own videos, all in HD. Join Vimeo. Log in Ny data öppnar för fas 3-studie nästa år Cantargia meddelade i dagarna att bolaget ska Vi tror att den trend som CAN04 visade upp i de preliminära data som "Dessa data är mycket lovande för utvecklingen av CAN04.

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Our development program includes the product candidate CAN04, presented novel preclinical data on antibody cantargia kurs CAN04 at the

The new data was generated using immunohistochemistry in tumor samples from 15 patients.